Which condition is marked by localized swelling under the skin, often affecting the eyes and lips?

Angioedema is characterized by rapid and localized swelling of the deeper layers of the skin, often occurring around the eyes and lips. This condition can be triggered by allergic reactions, medications, or other factors, leading to the release of histamine and other mediators from mast cells, resulting in the swelling. Unlike general edema, which may involve larger areas of the body and is tied to fluid retention or systemic conditions, angioedema is more specific and localized, making it easily identifiable by the swelling in particular areas. Its association with allergic reactions can also make it a critical condition that requires prompt recognition and management, particularly if it poses a risk to the airway.